Ken Dodd, MD on Twitter: "Fixed-Dosing of 1,500 units of the four-factor prothrombin complex concentrate Kcenta (compared to variable dosing) 1. Effectively corrects INR < 2.0 2. Decreases time to reversal 3.
![Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study | Trials | Full Text Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study | Trials | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13063-021-05524-x/MediaObjects/13063_2021_5524_Fig1_HTML.png)
Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study | Trials | Full Text
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The benefit of prothrombin complex concentrate in decreasing neurological deterioration in patients with warfarin-associated intracerebral haemorrhage | HKMJ
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Comparison of Hemostatic Outcomes in Patients Receiving Fixed-Dose vs. Weight-Based 4-Factor Prothrombin Complex Concentrate - ScienceDirect
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Prothrombin Complex Concentrate at Rs 28000/bottle | Green Park Extension | New Delhi | ID: 11430353048
![PDF] Activated prothrombin complex concentrates for the reversal of anticoagulant-associated coagulopathy. | Semantic Scholar PDF] Activated prothrombin complex concentrates for the reversal of anticoagulant-associated coagulopathy. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/80579c3b1fb5e450d3f8900ab88555932a952df1/3-Table1-1.png)
PDF] Activated prothrombin complex concentrates for the reversal of anticoagulant-associated coagulopathy. | Semantic Scholar
Evaluation of the prothrombotic potential of four-factor prothrombin complex concentrate (4F-PCC) in animal models | PLOS ONE
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LEX-211 (FARES-II): a phase 3, prospective, active-control randomised study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients - ISTH Congress Abstracts
![COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL | Journal of the American College of Cardiology COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL | Journal of the American College of Cardiology](https://www.jacc.org/cms/asset/089399ff-828c-4c7c-ac6f-a9dbe8e23cb3/s0735-1097(19)32742-1.fp.png)
COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL | Journal of the American College of Cardiology
![Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial - The Lancet Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial - The Lancet](https://www.thelancet.com/cms/attachment/e8ab2b80-7edb-40bd-8c91-7fa272263860/gr1.gif)
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial - The Lancet
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Safety and effectiveness of a four-factor prothrombin complex concentrate for vitamin K antagonist reversal following a fixed-dose strategy | European Journal of Hospital Pharmacy
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Propensity score adjusted comparison of three-factor versus four-factor prothrombin complex concentrate for emergent warfarin reversal: a retrospective cohort study | BMC Emergency Medicine | Full Text
![Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding | Circulation Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding | Circulation](https://www.ahajournals.org/cms/asset/eee56cb7-8e2a-4f34-9797-b1ea01fb8716/circulationaha.113.005107.fp.png)
Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding | Circulation
![Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial - The Lancet Neurology Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial - The Lancet Neurology](https://www.thelancet.com/cms/attachment/2053239570/2060116756/gr1.gif)
Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial - The Lancet Neurology
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